Dolutegravir drug-drug interactions

نویسندگان

چکیده

Dolutegravir is neither an inducer nor inhibitor of metabolising enzymes, and it therefore has a low propensity to act as perpetrator drug-drug interactions. Clinically significant decreases in dolutegravir exposure occur when co-administered with strong inducers (e.g. rifampicin, efavirenz) drug enzymes efflux transporters for which substrate – this can be overcome by increasing the dose from 50 mg once daily twice daily. significantly increases metformin plasma exposure: one must not exceed 500 concomitant dolutegravir. Divalent or trivalent cations chelate Therefore, administration aluminium- calcium-containing antacids should avoided. administered calcium iron supplements, provided these are taken together food.

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ژورنال

عنوان ژورنال: South African Medical Journal

سال: 2022

ISSN: ['0256-9574', '2078-5135']

DOI: https://doi.org/10.7196/samj.2021.v112i3.16316